Take the Hermann/New Florence exit (#175). Go south on Highway 19 about 15 miles and cross the Missouri River Bridge into Hermann. At the four-way stop turn left on East Fourth Street. You'll find the museum at the corner of Fourth and Schiller streets.
Take Highway 100 West through New Haven and into Hermann. Turn left on Highway 19 (Market Street). At the four-way stop turn left on East Fourth Street. You'll find the museum at the corner of Fourth and Schiller streets.
Take Interstate 44 east to Highway 19 (Exit 208 at Cuba). Go north about 50 miles to Hermann. At the four-way stop turn right on East Fourth Street. You'll find the museum at the corner of Fourth and Schiller streets.